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Question 114
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U3 80 TRUEMAN'S ELEMENTARY BIOLOGY proteins while unrelated species have fewer common proteins. Thus protein proximity shows evolutionary relationship. Proteins are variously folded linear heteropolymers of amino acids. The linear poly mess of aminoacids are called nolypentides A protein may have one polypeptide (monomeric proteins, e.g., myoglobin, ribonuclease), two polypeptides (e.g., insulin), four polypeptides ( in haemoglobin) or more ( 24 in ribulose biphosphate carboxylase and 72 in pyruvate dehydrogenase complex). A protein having two or more polypeptides is called multimer or multimeric protein. The common multimers are dimers, trimers, tetramers, pentamers and decamers. A polypeptide contains from a few (21 and 30 in the two polypeptides of human insulin, 97 in spinach ferredoxin) to a few hundred amino acid residues ( 582 in human serum albumin). The amino acids are linked serially by peptide bonds formed between amino group of one amino acid and carboxylic group of the adjacent one. Collagen is most abundant protein of animal worlda Rubisco (ribulose biphosphate carboxylase-oxygenase) is not only the most abundant protein in plants but also the whole biosphere. Organisation (Levels of Structure) While physicists study three dimensional structures of macromolecules, biologists study protein structure upto four levels of organisation-primary, secondary, tertiary and quarternary. 1. Primary Structure (Fig. 9.12). It is the description of basic structure of a protein. This includes number of polypeptides, number and sequence of amino latter is determined genetically (by DNA) through transcription and translation. Specific amino acids determine the places where polypeptides are to bend or fold and where the different lengths will be attracted to each other. The distance between two adjacent pentide bonds is about of the protein primary structure is represented by the first amino Fig. 9.12. Primary structure of a protein. and represent acid while the right end is first and last termini. Three letter and one letter codę of represented by last amino acid (C).
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