World's only instant tutoring platform
Search questions and Textbooks
dropdown-logo
Get 2 FREE Instant-Explanations on Filo with code FILOAPP
Question

Question asked by Filo student

Which of the following does not contribute to the high salt concentration in the interstitial fluid of the kidney medulla?(a) active transport of sodium from the upper part of the ascending limb (b) diffusion of salt from the ascending limb of the loop of Henle (c) reabsorption of salt from variOus regions of Bowman's capsule (d) counterflow of fluid through the two limbs of the loop of Henle (e) diffusion of urea out of the collecting duct

tutor 0tutor 1tutor 2
Found 6 tutors discussing this question
Discuss this question LIVE
5 mins ago
Video Solution

Filo tutor solution

Learn from their 1-to-1 discussion with Filo tutors.

Solution Available
Generate FREE solution for this question from our expert tutors in next 60 seconds
Don't let anything interrupt your homework or exam prep with world’s only instant-tutoring, available 24x7
filo Logo

Students who ask this question also asked

Question 1
Views

Views: 5,805

Research Proposal: Investigating Altered Arginine Metabolism as a Therapeutic or Biomarker Discovery for Alzheimer's Disease Hypothesis and Aims: The hypothesis of this research proposal is that targeting altered arginine metabolism can lead to therapeutic interventions or biomarker discoveries for Alzheimer's disease. The specific aims of this study are to: 1. Investigate the role of arginine metabolism in the pathogenesis of Alzheimer's disease. 2. Identify potential therapeutic targets within the arginine metabolic pathway. 3. Explore the potential of arginine metabolites as biomarkers for early detection and monitoring of Alzheimer's disease progression. The techniques that will be used to achieve these aims include: 1. Metabolomic analysis: Utilizing mass spectrometry-based techniques to quantify and compare arginine metabolites in Alzheimer's disease patients and healthy controls. 2. Cell culture experiments: Culturing neuronal cells and treating them with arginine pathway modulators to assess their impact on amyloid-beta production and tau phosphorylation. 3. Animal models: Utilizing transgenic mouse models of Alzheimer's disease to investigate the effects of manipulating arginine metabolism on cognitive function and neuropathology. Research Plan - Methodology: 1. Metabolomic Analysis: - Number of groups: Two groups - Alzheimer's disease patients and age-matched healthy controls. - Number of participants: 50 participants per group. - Time points: Blood samples will be collected at baseline and at regular intervals (e.g., every 6 months) for a period of 2 years. - Controls: Age-matched healthy individuals without any cognitive impairment. - Experimental details: Liquid chromatography-mass spectrometry (LC-MS) will be used to quantify arginine metabolites. Statistical analysis will involve multivariate data analysis and correlation analysis. 2. Cell Culture Experiments: - Number of groups: Two groups - control group and arginine pathway modulator-treated group. - Number of participants: N/A (in vitro study). - Time points: Cells will be treated with arginine pathway modulators for a specific duration (e.g., 24 hours). - Controls: Untreated cells. - Experimental details: Immunoblotting and immunofluorescence techniques will be used to assess amyloid-beta production and tau phosphorylation. Statistical analysis will involve t-tests or ANOVA followed by post-hoc tests. Significance and Potential Outcomes: The expected outcomes of this research include: - Identification of specific arginine metabolites that are dysregulated in Alzheimer's disease. - Discovery of potential therapeutic targets within the arginine metabolic pathway. - Validation of arginine metabolites as biomarkers for early detection and monitoring of Alzheimer's disease progression. The new knowledge contributed by this work will enhance our understanding of the role of altered arginine metabolism in Alzheimer's disease and provide insights into potential therapeutic interventions and biomarker development. However, there are limitations to this approach, such as the complexity of the disease and the need for further validation in larger cohorts. This research could lead to follow-on experiments, such as investigating the efficacy of targeting specific arginine metabolites in animal models or clinical trials. The overall significance of this proposed work lies in its potential to contribute to the development of novel therapeutic strategies and improved diagnostic tools for Alzheimer's disease, ultimately leading to better patient outcomes and a deeper understanding of the disease's pathogenesis.
View more
Question Text
Which of the following does not contribute to the high salt concentration in the interstitial fluid of the kidney medulla?(a) active transport of sodium from the upper part of the ascending limb (b) diffusion of salt from the ascending limb of the loop of Henle (c) reabsorption of salt from variOus regions of Bowman's capsule (d) counterflow of fluid through the two limbs of the loop of Henle (e) diffusion of urea out of the collecting duct
TopicAll topics
SubjectBiology
ClassClass 11