The Chemistry of DNA Replication All DNA polymerases synthesize new DNA strands in the $5^{'} \to 3^{'}$ direction. In some respects, replication of the antiparallel strands of duplex DNA would be simpler if there were also a second type of polymerase, one that synthesized DNA in the $3^{'} \to 5^{'}$ direction. The two types of polymerase could, in principle, coordinate DNA synthesis without the complicated mechanics required for lagging strand replication. However, no such $3^{'} \to 5^{'}$ -synthesizing enzyme has been found. Suggest two possible mechanisms for $3^{'} \to 5^{'}$ DNA synthesis. Pyrophosphate should be one product of both proposed reactions. Could one or both mechanismsbe supported in a cell? Why or why not? (Hint: You may suggest the use of DNA precursors not actually present in extant cells.)

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The Chemistry of DNA Replication All DNA polymerases synthesize new DNA strands in the

5^{'} \to 3^{'}

direction. In some respects, replication of the antiparallel strands of duplex DNA would be simpler if there were also a second type of polymerase, one that synthesized DNA in the

3^{'} \to 5^{'}

direction. The two types of polymerase could, in principle, coordinate DNA synthesis without the complicated mechanics required for lagging strand replication. However, no such

3^{'} \to 5^{'}

-synthesizing enzyme has been found. Suggest two possible mechanisms for

3^{'} \to 5^{'}

DNA synthesis. Pyrophosphate should be one product of both proposed reactions. Could one or both mechanismsbe supported in a cell? Why or why not? (Hint: You may suggest the use of DNA precursors not actually present in extant cells.)

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Question Text	The Chemistry of DNA Replication All DNA polymerases synthesize new DNA strands in the $5^{'} \to 3^{'}$ direction. In some respects, replication of the antiparallel strands of duplex DNA would be simpler if there were also a second type of polymerase, one that synthesized DNA in the $3^{'} \to 5^{'}$ direction. The two types of polymerase could, in principle, coordinate DNA synthesis without the complicated mechanics required for lagging strand replication. However, no such $3^{'} \to 5^{'}$ -synthesizing enzyme has been found. Suggest two possible mechanisms for $3^{'} \to 5^{'}$ DNA synthesis. Pyrophosphate should be one product of both proposed reactions. Could one or both mechanismsbe supported in a cell? Why or why not? (Hint: You may suggest the use of DNA precursors not actually present in extant cells.)
Topic	All topics
Subject	Biology
Class	Class 11

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