Recall that Carlos' blood creatinine level is very high, which supports a diagnosis of acute renal failure. Which of the following statements is true with regard to renal clearance?

1. Renal clearance measures the rate at which the kidneys remove a substance, such as creatinine, from the blood.
2. Renal clearance and GFR are completely unrelated.
3. Creatinine is a more accurate assessment of GFR than inulin.
4. Creatinine is the perfect substance to measure GFR and renal clearance because creatinine is neither secreted nor reabsorbed and is completely filtered.

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