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Question 5 The graph below summarizes the changes in surface antigens on the trypanosome parasite during its life cycle in a human host. A: Anti-VSG population #1 Anti-VSG population #2 Anti-VSG population #3 Anti-VSG population #4 Parasite load Course of infection A: By what mechanism is the VSG antigen switched in order to evade the host defenses? B: In addition to antigen switching, how else does the sleeping sickness parasite evade the immune system?

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Texts: History A 5-year-old boy has been seen by his pediatrician for an extensive skin rash. The mother, a 3-month pregnant woman, explains that her son started school last week, and that he "has not been himself" for the last few days, showing typical flu-like symptoms with a mild fever, general achiness, and a mild sore throat. When asked by the doctor, she admitted that for personal reasons, she did not vaccinate any member of her family, being afraid that they may develop autism. Vital signs: temperature of 39 °C (102.2°F), pulse 104/min, blood pressure 126/68 mmHg. The child has diffuse vesiculopustular lesions over the entire body, with some areas showing older, crusted lesions. He has cellulitis in his right hand, manifested by marked erythema, swelling, and tenderness. There are no mouth lesions, and the liver and spleen are not tender nor enlarged. -Based on the history and vital signs, which pathogen do you think is responsible for the infection? Precisely how do you eliminate the other pathogens? List of possible pathogens: • Staphylococcus aureus • Streptococcus pyogenes • Chickenpox virus • Measles virus • Rubella virus -What treatment would you recommend? -How frequent is this infection in the US? -Are there any risks of complications associated with the infection? -Would you recommend the family to be treated? -Is there any concern with the mother's pregnancy? -What could have prevented this infection? -Is the mother's attitude toward vaccination justified?
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Question 5 The graph below summarizes the changes in surface antigens on the trypanosome parasite during its life cycle in a human host. A: Anti-VSG population #1 Anti-VSG population #2 Anti-VSG population #3 Anti-VSG population #4 Parasite load Course of infection A: By what mechanism is the VSG antigen switched in order to evade the host defenses? B: In addition to antigen switching, how else does the sleeping sickness parasite evade the immune system?
TopicAll topics
SubjectBiology
ClassClass 11