Please, I need help with these questions (short written answers) for all of them, please! Thank you so much. I promise I will thumbs up! Questions:

1. Sustaining proliferative signaling is one of the hallmarks of cancer. Provide a description of this hallmark and one mechanism of action that cells acquire to establish this hallmark.
2. Genome instability and mutation are described as an enabling characteristic instead of a hallmark of cancer. Describe genome instability and explain why it is classified as an enabling characteristic.
3. Pick one hallmark of cancer other than sustaining proliferative signaling and describe the hallmark and explain how genome instability specifically contributes to that hallmark and cancer progression.
4. Beginning from an intact epithelial layer, describe the process of development of a carcinoma (Make sure to use appropriate nomenclature and terminology): Start at the beginning of abnormal growth and describe the changes in growth characteristics.
5. Conclude with the invasion and metastasis cascade and the formation of micrometastasis.
6. The Ames Test is used to determine whether a chemical is a mutagen. The mutagenic potential of a compound can then be compared to its carcinogenic potential. Describe how the Ames Test works and how it was used to correlate mutagenesis and carcinogenesis.

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