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In higher eukaryotic cells, nuclear localization signals in a
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In higher eukaryotic cells, nuclear localization signals in a protein are not cleaved off after transport into the nucleus, whereas the signal sequences for import into other organelles are often removed after import. Why do you think it is critical for nuclear localization signals remain attached to their proteins? I see that many people use mitosis as a reason for why the NLS signal is not cleaved off, but we have not discussed mitotic cell division in this class at all, which leads me to think that my professor expects an answer unrelated to that. Could you provide an example that does not use mitosis as a reason to keep the NLS sequence?

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In higher eukaryotic cells, nuclear localization signals in a protein are not cleaved off after transport into the nucleus, whereas the signal sequences for import into other organelles are often removed after import. Why do you think it is critical for nuclear localization signals remain attached to their proteins? I see that many people use mitosis as a reason for why the NLS signal is not cleaved off, but we have not discussed mitotic cell division in this class at all, which leads me to think that my professor expects an answer unrelated to that. Could you provide an example that does not use mitosis as a reason to keep the NLS sequence?
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Question Text
In higher eukaryotic cells, nuclear localization signals in a protein are not cleaved off after transport into the nucleus, whereas the signal sequences for import into other organelles are often removed after import. Why do you think it is critical for nuclear localization signals remain attached to their proteins? I see that many people use mitosis as a reason for why the NLS signal is not cleaved off, but we have not discussed mitotic cell division in this class at all, which leads me to think that my professor expects an answer unrelated to that. Could you provide an example that does not use mitosis as a reason to keep the NLS sequence?
TopicAll topics
SubjectBiology
ClassClass 11