Once an activated signaling pathway has elicited the proper changes in target gene expression, the pathway must be inactivated. Otherwise, pathologic consequences may result, as exemplified by persistent growth factor-initiated signaling in many cancers. Many signaling pathways possess intrinsic negative feedback by which a downstream event in a pathway turns off an upstream event. Describe the negative feedback that down-regulates signals induced by(a) erythropoietin and(b) $TGF - β$

Views: 5,046 students

Found 4 tutors discussing this question

Mila Discussed

Once an activated signaling pathway has elicited the proper changes in target gene expression, the pathway must be inactivated. Otherwise, pathologic consequences may result, as exemplified by persistent growth factor-initiated signaling in many cancers. Many signaling pathways possess intrinsic negative feedback by which a downstream event in a pathway turns off an upstream event. Describe the negative feedback that down-regulates signals induced by(a) erythropoietin and(b)

TGF - β

12 mins ago

Discuss this question LIVE

12 mins ago

Question Text	Once an activated signaling pathway has elicited the proper changes in target gene expression, the pathway must be inactivated. Otherwise, pathologic consequences may result, as exemplified by persistent growth factor-initiated signaling in many cancers. Many signaling pathways possess intrinsic negative feedback by which a downstream event in a pathway turns off an upstream event. Describe the negative feedback that down-regulates signals induced by(a) erythropoietin and(b) $TGF - β$
Topic	All topics
Subject	Biology
Class	Class 11

Filo tutor solution

Practice more questions on All topics

Students who ask this question also asked