Effects of a Deleted Insulin Receptor A strain of mice specifically lacking the insulin receptor of liver is found to have mild fasting hyperglycemia (blood glucose $= 132 mg / dL$ , vs. $101 mg / dL in controls)$ and a more striking hyperglycemia in the fed state (glucose $= 363 mg / dL, vs. 135 mg / dL in controls) .$ The mice have higher than normal levels of glucose 6 -phosphatase in the liver and elevated levels of insulin in the blood. Explain these observations.

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Effects of a Deleted Insulin Receptor A strain of mice specifically lacking the insulin receptor of liver is found to have mild fasting hyperglycemia (blood glucose

= 132 mg / dL

, vs.

101 mg / dL in controls)

and a more striking hyperglycemia in the fed state (glucose

= 363 mg / dL, vs. 135 mg / dL in controls) .

The mice have higher than normal levels of glucose 6 -phosphatase in the liver and elevated levels of insulin in the blood. Explain these observations.

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Question Text	Effects of a Deleted Insulin Receptor A strain of mice specifically lacking the insulin receptor of liver is found to have mild fasting hyperglycemia (blood glucose $= 132 mg / dL$ , vs. $101 mg / dL in controls)$ and a more striking hyperglycemia in the fed state (glucose $= 363 mg / dL, vs. 135 mg / dL in controls) .$ The mice have higher than normal levels of glucose 6 -phosphatase in the liver and elevated levels of insulin in the blood. Explain these observations.
Topic	All topics
Subject	Biology
Class	Class 12

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