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Chapter 1: Reproduction in Organisms
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Chapter 3: Human Reproduction
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Chapter 4: Reproductive Health
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Chapter 12: Biotechnology and its Applications
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Q1
What are Cry proteins? Name an organism that produce it. How has man exploited this protein to his benefit?
Q2
What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency.
Q3
Digrammatically represent the experimental steps in cloning and expressing an human gene (say the gene for growth hormone) into a bacterium like E. coli ?
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What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency.
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Gene therapy is the process of introduction of DNA into an organism e.g. human beings in order to treat a disease. It is used to replace a missing gene product or to correct mutant alleles. ADA is an autosomal-recessive inherited disorder that occurs due to defective adenosine deaminase (ADA) enzyme. Please with this enzyme deficiency suffer from severe combined immunodeficiency (SCID) conditions. Human gene therapy trial can be used for ex vivo introduction of functional ADA gene in bone marrow cells of the patient, suffering from SCID. For this process, an engineered retrovirus containing a functional ADA gene is used to transfer the ADA gene into stem cells isolated from the patient with SCID. The treated cells or modified cells with the good ADA gene are reintroduced into the patient’s marrow.
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| Question Text | What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency. |
| Topic | Biotechnology and its Applications |
| Subject | Biology |
| Class | Class 12 |
| Answer Type | Text solution:1 |
| Upvotes | 13 |
