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How did Eli Lily synthesize human insulin? Mention one difference between this insulin and the one produced by the human pancreas.
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Eli Lily, 1993 synthesized human insulin using recombinant DNA technology. They prepared two DNA sequences corresponding to A & B chains of human insulin and introduced them to plasmids of to produce insulin chains. Chains A & B were produced separately, extracted, and combined by creating disulfide bonds to form human insulin.
The insulin so produced was called humalin and is different from naturally produced insulin because it is produced in the mature form while the human insulin is produced in the proinsulin form having an extra stretch called C-peptide.
The insulin so produced was called humalin and is different from naturally produced insulin because it is produced in the mature form while the human insulin is produced in the proinsulin form having an extra stretch called C-peptide.
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| Question Text | How did Eli Lily synthesize human insulin? Mention one difference between this insulin and the one produced by the human pancreas. |
| Topic | Biotechnology and its Applications |
| Subject | Biology |
| Class | Class 12 |
| Answer Type | Text solution:1 |
| Upvotes | 141 |
